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Abdul Barakat's Cardiovascular and Cellular Engineering Lab

Research

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Endothelial cell mechanosensing and mechanotransduction

This research project is devoted to understanding how mechanical force is transmitted through intracellular structures (cytoskeleton) and how the intracellular biochemical signal elicited mechanically can be efficiently modified.


 

Early atherosclerotic lesions localize preferentially in arterial regions that are exposed to low flow rate and/or oscillatory flow. Development of these lesions involves dysfunction of the vascular endothelium, the monolayer of cells lining the inner surface of all blood vessels. Therefore, understanding intracellular processes (mechanotransduction), by which mechanical stimuli are translated into intracellular biochemical responses, has been an important research issue. Our current research projects are, therefore, devoted to understanding how mechanical force is transmitted through intracellular structures (cytoskeleton)  and how the intracellular biochemical signal elicited mechanically can be efficiently modified. These projects are being pursued actively by constructing conceptual mathematical models for intracellular physiology at the molecular and cellular level.